Items where Author is "Clench, Malcolm"

PEARCE, Sophie, CROSS, Neil A, SMITH, David P, CLENCH, Malcolm, FLINT, Lucy E., HAMM, Gregory, GOODWIN, Richard, LANGRIDGE, James I, CLAUDE, Emmanuelle and COLE, Laura (2024). Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response. Metabolites, 14 (6): 315. [Article]

VOLOACA, Oana M, CLENCH, Malcolm, KOELLENSPERGER, Gunda, COLE, Laura, HAYWOOD-SMALL, Sarah and THEINER, Sarah (2022). Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA-ICP-TOFMS Imaging. Analytical Chemistry, 94, 2597-2606. [Article]

SPENCER, Chloe E., FLINT, L.E., DUCKETT, Catherine, COLE, Laura, CROSS, Neil, SMITH, David and CLENCH, Malcolm (2021). Role of MALDI-MSI in combination with 3D tissue models for early stage efficacy and safety testing of drugs and toxicants. Expert Review of Proteomics, 17 (11-12), 827-841. [Article]

PÉREZ-LÓPEZ, Arely V., SIMPSON, June, CLENCH, Malcolm, GOMEZ-VARGAS, Alan D. and ORDAZ-ORTIZ, José J. (2021). Localization and Composition of Fructans in Stem and Rhizome of Agave tequilana Weber var. azul. Frontiers in Plant Science, 11, p. 608850. [Article]

HANDLER, Anne Mette, POMMERGAARD PEDERSEN, Gitte, TROENSEGAARD NIELSEN, Kim, JANFELT, Christian, JUST PEDERSEN, Anders and CLENCH, Malcolm (2020). Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin. European Journal of Pharmaceutics and Biopharmaceutics, 159, 1-10. [Article]

FLINDERS, Bryn, MORRELL, Josie, MARSHALL, Peter S, RANSHAW, Lisa E, HEEREN, Ron MA and CLENCH, Malcolm (2020). Monitoring the three-dimensional distribution of endogenous species in the lungs by matrix-assisted laser desorption/ionization mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 35 (1), e8957. [Article]

RUSSO, C., HEATON, C., FLINT, L., VOLOACA, Oana, HAYWOOD-SMALL, Sarah, CLENCH, Malcolm, FRANCESE, Simona and COLE, Laura (2020). Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging, 9, 1-21. [Article]

YUTUC, Eylan, ANGELINI, Roberto, BAUMERT, Mark, MAST, Natalia, PIKULEVA, Irina, NEWTON, Jillian, CLENCH, Malcolm, SKIBINSKI, David O.F., HOWELL, Owain W., WANG, Yuqin and GRIFFITHS, William J. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, p. 201917421. [Article]

PALUBECKAITĖ, Ieva, CROOKS, Lucy, SMITH, David, COLE, Laura, BRAM, Heijs, LE MAITRE, Christine, CLENCH, Malcolm and CROSS, Neil A (2019). Mass spectrometry imaging of endogenous metabolites in response to doxorubicin in a novel 3D osteosarcoma cell culture model. Journal of Mass Spectrometry. [Article]

COLE, Laura, CLENCH, Malcolm and FRANCESE, Simona (2019). Sample treatment for tissue proteomics in cancer, toxicology, and forensics. In: CAPELO-MARTINEZ, Jose-Luis, (ed.) Emerging sample treatments in proteomics. Advances in Experimental Medicine and Biology (1073). Springer, 77-123. [Book Section]

HARDING, AJ, HOUGH, J, CURTIS, C, KINSMAN, D and CLENCH, Malcolm (2019). Matrix-assisted ionisation in vacuum mass spectrometry and imaging on a modified quadrupole-quadrupole-time-of-flight mass spectrometer. Journal of Spectral Imaging, 8, a12. [Article]

RUSSO, Cristina, BRICKELBANK, Neil, DUCKETT, Catherine, MELLOR, Steve, RUMBELOW, Stephen and CLENCH, Malcolm (2018). Quantitative investigation of terbinafine hydrochloride absorption into a living skin equivalent model by MALDI-MSI. Analytical chemistry, 90 (16), 10031-10038. [Article]

RUSSO, Cristina, LEWIS, Emily, FLINT, Lucy and CLENCH, Malcolm (2018). Mass spectrometry imaging of 3D tissue models. Proteomics, 18 (14). [Article]

SWALES, John, DEXTER, Alex, HAMM, Gregory, NILSSON, Anna, STRITTMATTER, Nicole, MICHOPOULOS, Filippos, HARDY, Christopher, MORENTIN-GUTIERREZ, Pablo, MELLOR, Martine, ANDREN, Per E., CLENCH, Malcolm, BUNCH, Josephine, CRITCHLOW, Susan E. and GOODWIN, Richard J. A. (2018). Quantitation of endogenous metabolites in mouse tumors using mass-spectrometry imaging. Analytical Chemistry, 90 (10), 6051-6058. [Article]

LEWIS, E E L, BARRETT, M R T, FREEMAN-PARRY, Louise, BOJAR, R A and CLENCH, Malcolm (2018). Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). International journal of cosmetic science, 40 (2), 148-156. [Article]

WOJAKOWSKA, A, COLE, Laura, CHEKAN, M, BEDNARCZYK, K, MAKSYMIAK, M, OCZKO-WOJCIECHOWSKA, M, JARZĄB, B, CLENCH, Malcolm, POLAŃSKA, J, PIETROWSKA, M and WIDLAK, P (2018). Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging. Endokrynologia Polska, 69 (1), 2-8. [Article]

FLINDERS, Bryn, BEASLEY, Emma, VERLAAN, Ricky M., CUYPERS, Eva, FRANCESE, Simona, BASSINDALE, Thomas, CLENCH, Malcolm and HEEREN, Ron M. A. (2017). Optimization of sample preparation and instrumental parameters for the rapid analysis of drugs of abuse in hair samples by MALDI-MS/MS imaging. Journal of the American Society for Mass Spectrometry, 28 (11), 2462-2468. [Article]

LEESE, Elizabeth, CLENCH, Malcolm, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2017). The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis. Toxics, 5 (2), p. 12. [Article]

MARTIN, Scott, LENZ, Eva M, SMITH, Robin, TEMESI, David G, ORTON, Alexandra L and CLENCH, Malcolm (2017). Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM, 31 (1), 145-151. [Article]

SWALES, John G., STRITTMATTER, Nicole, TUCKER, James W., CLENCH, Malcolm, WEBBORN, Peter J. H. and GOODWIN, Richard J. A. (2016). Spatial quantitation of drugs in tissues using liquid extraction surface analysis mass spectrometry imaging. Scientific Reports, 6, p. 37648. [Article]

MITCHELL, C.A., LONG, H., DONALDSON, M., FRANCESE, S. and CLENCH, Malcolm (2015). Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling. Lipids in Health and Disease, 14 (1), p. 84. [Article]

FLINDERS, Bryn, MORRELL, Josie, MARSHALL, Peter S., RANSHAW, Lisa E. and CLENCH, Malcolm (2015). The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI. Analytical and Bioanalytical Chemistry, 407 (8), 2085-2094. [Article]

WRIGHT, Chris, REED, Heath, PARTRIDGE, Rebecca, COLE, Laura, SELVAN, Arul and CLENCH, Malcolm (2014). Communication of multi-modal imaging: MRI, MSI, and histology. In: BCISMRM, Edinburgh, 4-5th September 2014. (Unpublished) [Conference or Workshop Item]

COLE, Laura, BLUFF, Joanne E., CAROLAN, Vikki, PALEY, Martyn N., TOZER, Gillian M. and CLENCH, Malcolm (2014). MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent. Proteomics, 14 (7-8), 890-903. [Article]

SWALES, John G., TUCKER, James W., STRITTMATTER, Nicole, NILSSON, Anna, COBICE, Diego, CLENCH, Malcolm, MACKAY, C. Logan, ANDREN, Per E., TAKÁTS, Zoltán, WEBBORN, Peter J. H. and GOODWIN, Richard J. A. (2014). Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis. Analytical chemistry, 86 (16), 8473-8480. [Article]

COLE, Laura, MAHMOUD, Khaled, HAYWOOD-SMALL, Sarah, TOZER, Gillian M., SMITH, David and CLENCH, Malcolm (2013). Recombinant "IMS TAG" proteins : a new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 27 (21), 2355-2362. [Article]

COLE, Laura, DJIDJA, M-C, BLUFF, J., CLAUDE, E, CAROLAN, Vikki, PALEY, M, TOZER, G M and CLENCH, Malcolm (2011). Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI. Methods, 54 (4), 442-453. [Article]

SWALES, John G., HAMM, Gregory, CLENCH, Malcolm and GOODWIN, Richard J.A. (2018). Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review. International Journal of Mass Spectrometry. [Article]

SLOWINSKA, M, SALLEM, H, CLENCH, Malcolm and CIERESZKO, A (2018). Metabolomic analysis of white and yellow seminal plasma in turkeys (Meleagris gallopavo)1. Poultry science, 97 (3), 1059-1065. [Article]

DJIDJA, Marie-Claude, CLAUDE, Emmanuelle, SCRIVEN, Peter, ALLEN, David, CAROLAN, Vikki and CLENCH, Malcolm (2016). Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues. Biochimica et biophysica acta, 1865 (7), 901-906. [Article]

MITCHELL, Christopher A., DONALDSON, Michael, FRANCESE, Simona and CLENCH, Malcolm (2016). MALDI MSI analysis of lipid changes in living skin equivalents in response to emollient creams containing palmitoylethanolamide. Methods, 104, 93-100. [Article]

CURTIS, Angela, MORTON, Jackie, FRASER, Susan, HARDING, Anne-Helen, PRIDEAUX, Brendan, CLENCH, Malcolm, WARREN, Nicholas D. and EVANS, Gareth S. (2015). Can the KG1 cell line be used as a model of dendritic cells and discriminate the sensitising potential of chemicals? Toxicology Letters, 239 (1), 32-40. [Article]

SWALES, John G., TUCKER, James W., SPREADBOROUGH, Michael J., IVERSON, Suzanne L., CLENCH, Malcolm, WEBBORN, Peter J. H. and GOODWIN, Richard J. A. (2015). Mapping drug distribution in brain tissue using liquid extraction surface analysis mass spectrometry imaging. Analytical Chemistry, 87 (19), 10146-10152. [Article]

PATEL, Ekta, CLENCH, Malcolm, WEST, Andy, MARSHALL, Peter S., MARSHALL, Nathan and FRANCESE, Simona (2015). Alternative Surfactants for Improved Efficiency of In Situ Tryptic Proteolysis of Fingermarks. Journal of The American Society for Mass Spectrometry, 26 (6), 862-872. [Article]

COLE, Laura and CLENCH, Malcolm (2015). Mass spectrometry imaging for the proteomic study of clinical tissue. PROTEOMICS - Clinical Applications, 9 (3-4), 335-341. [Article]

PATEL, Ekta, COLE, Laura M, BRADSHAW, Robert, BATUBARA, Afnan, MITCHELL, Christopher A, FRANCESE, Simona and CLENCH, Malcolm (2015). MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics. Bioanalysis, 7 (1), 91-101. [Article]

COLE, Laura, SELVAN, Arul, WRIGHT, Chris, REED, Heath and CLENCH, Malcolm (2014). Communication of medical images to diverse audiences using multiple imaging modalities'. In: BMSS Annual Meeting 2014, Alderley Park Conference Centre, Macclesfield, Cheshire., 1st-2nd April 2014. [Conference or Workshop Item]

BRADSHAW, Robert, BLEAY, S, CLENCH, Malcolm and FRANCESE, Simona (2014). Direct detection of blood in fingermarks by MALDI MS profiling and imaging. Science & justice, 54 (2), 110-7. [Article]

DJIDJA, Marie-Claude, FRANCESE, Simona, CLAUDE, Emmanuelle, LOADMAN, Paul, SUTTON, Chris, SHYNDER, Steve, COOPER, Patricia, PATTERSON, Laurence H, CAROLAN, Vikki and CLENCH, Malcolm (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225. [Article]

MAHMOUD, Khaled, COLE, Laura, NEWTON, Jillian, MOHAMED, Sabah, AL-ENAZI, Maher, QIRKE, Phil and CLENCH, Malcolm (2013). Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging. European Journal of Mass Spectrometry, 19 (1), 17-28. [Article]

DAHLAWI, Haytham, JORDAN-MAHY, Nikki, CLENCH, Malcolm, MCDOUGALL, Gordon J. and LE MAITRE, Christine (2013). Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines. Food Science and Nutrition, 1 (2), 196-208. [Article]

BRADSHAW, Robert, BLEAY, Stephen, WOLSTENHOLME, Rosalind, CLENCH, Malcolm and FRANCESE, Simona (2013). Towards the integration of matrix assisted laser desorption ionisation mass spectrometry imaging into the current fingermark examination workflow. Forensic Science International, 232 (1-3), 111-124. [Article]

SEPPALA, Ulla, FRANCESE, Simona, TURILLAZI, Stefano, MONETI, Gloriano, CLENCH, Malcolm and BARBER, Domingo (2012). In situ imaging of honeybee (Apis mellifera) venom components from aqueous and aluminum hydroxide-adsorbed venom immunotherapy preparations. Journal of Allergy and Clinical Immunology, 129 (5), 1314-1320. [Article]

TRIM, Paul J, DJIDJA, Marie-Claude, MUHARIB, Tasneem, COLE, Laura M, FLINDERS, Bryn, CAROLAN, Vikki, FRANCESE, Simona and CLENCH, Malcolm (2012). Instrumentation and software for mass spectrometry imaging -making the most of what you've got. Journal of Proteomics, 75 (16), 4931-4940. [Article]

MARTIN, Scott, LENZ, Eva M., TEMESI, Dave, WILD, Martin and CLENCH, Malcolm (2012). Reaction of homopiperazine with endogenous formaldehyde. A carbon hydrogen addition metabolite/product identified in rat urine and blood. Drug Metabolism and Disposition, 40 (8), 1478-1486. [Article]

ZAINI, Rana G., BRANDT, Kirsten, CLENCH, Malcolm and LE MAITRE, Christine (2012). Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells. Anti-Cancer Agents in Medicinal Chemistry, 12 (6), 640-652. [Article]

DAHLAWI, H, JORDAN-MAHY, Nikki, CLENCH, Malcolm and LE MAITRE, Christine (2012). Bioactive actions of pomegranate fruit extracts on leukemia cell lines In vitro hold promise for new therapeutic agents for leukemia. Nutrition and Cancer, 64 (1), 100-110. [Article]

FERGUSON, Leesa Susanne, WULFERT, Florian, WOLSTENHOLME, Rosalind, FONVILLE, Judith Marlou, CLENCH, Malcolm, CAROLAN, Vikki Amanda and FRANCESE, Simona (2012). Direct detection of peptides and small proteins in fingermarks and determination of sex by MALDI mass spectrometry profiling. The Analyst, 137 (20), 4686-4692. [Article]

ZAINI, R, CLENCH, Malcolm and LE MAITRE, Christine (2011). Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia. Journal of Medicinal Food, 14 (11), 1-10. [Article]

COLE, L M, DJIDJA, M-C, BLUFF, J, CLAUDE, E, CAROLAN, V A, PALEY, M, TOZER, G M and CLENCH, Malcolm (2011). Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI. Methods, 54 (4), 442-453. [Article]

AVERY, Jennie L., MCKEWEN, Andrew, FLINDERS, Bryn, FRANCESE, Simona and CLENCH, Malcolm (2011). Matrix assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by straticell-RHE-EPI/001 an artificial model of the human epidermis. Xenobiotica, 41 (8), pp 735-742. [Article]

FERGUSON, Leesa, BRADSHAW, Robert, WOLSTENHOLME, Rosalind, CLENCH, Malcolm and FRANCESE, Simona (2011). Two-step matrix application for the enhancement and imaging of latent fingermarks. Analytical Chemistry, 83 (14), 5585-5591. [Article]

NEWTON, Jillian, PARKINSON, David and CLENCH, Malcolm Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms. . [Article]