Radiation-induced changes in serum lipidome of head and neck cancer patients

JELONEK, Karol, PIETROWSKA, Monica, ROS, Malgorzata, ZAGDANSKI, Adam, SUCHWALKO, Agnieszka, POLANSKA, Joanna, MARCZYK, Michal, RUTKOWSKI, Tomasz, SKLADOWSKI, Krzysztof, CLENCH, Malcolm R. and WIDLAK, Piotr (2014). Radiation-induced changes in serum lipidome of head and neck cancer patients. International Journal of Molecular Sciences, 15 (4), 6609-6624. [Article]

Documents
8596:561969
[thumbnail of ijms-15-06609.pdf]
Preview
PDF
ijms-15-06609.pdf - Published Version
Available under License Creative Commons Attribution.

Download (948kB) | Preview
Abstract
Cancer radiotherapy (RT) induces response of the whole patient’s body that could be detected at the blood level. We aimed to identify changes induced in serum lipidome during RT and characterize their association with doses and volumes of irradiated tissue. Sixty-six patients treated with conformal RT because of head and neck cancer were enrolled in the study. Blood samples were collected before, during and about one month after the end of RT. Lipid extracts were analyzed using MALDI-oa-ToF mass spectrometry in positive ionization mode. The major changes were observed when pre-treatment and within-treatment samples were compared. Levels of several identified phosphatidylcholines, including (PC34), (PC36) and (PC38) variants, and lysophosphatidylcholines, including (LPC16) and (LPC18) variants, were first significantly decreased and then increased in post-treatment samples. Intensities of changes were correlated with doses of radiation received by patients. Of note, such correlations were more frequent when low-to-medium doses of radiation delivered during conformal RT to large volumes of normal tissues were analyzed. Additionally, some radiation-induced changes in serum lipidome were associated with toxicity of the treatment. Obtained results indicated the involvement of choline-related signaling and potential biological importance of exposure to clinically low/medium doses of radiation in patient’s body response to radiation.
More Information
Statistics

Downloads

Downloads per month over past year

Metrics

Altmetric Badge

Dimensions Badge

Share
Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email

Actions (login required)

View Item View Item