Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

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BRADFORD, Claire M., RAMOS, Inês, CROSS, Alison K., HADDOCK, Gail, MCQUAID, Stephen, NICHOLAS, Anthony P. and WOODROOFE, M. Nicola (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95. [Article]

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8579:18822

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Abstract

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and control brain white matter. We demonstrate increased citrullinated GFAP and MBP by immunohistochemistry and western blotting in areas of ongoing demyelination, suggesting a pivotal role for deimination of GFAP and MBP in MS pathogenesis MS.

More Information

Official URL:

http://dx.doi.org/10.1016/j.jneuroim.2014.05.007

Research Institute, Centre or Group - Does NOT include content added after October 2018:

Biomedical Research Centre

Page Range:

85-95

Identifiers

Identification Number:

10.1016/j.jneuroim.2014.05.007

ORCID for Alison K. Cross: