Multi-scale interaction of particulate flow and the artery wall

Tools

HALLIDAY, I., ATHERTON, M., CARE, C., COLLINS, M. W., EVANS, D., EVANS, P. C., HOSE, D. R., KHIR, A. W., KÖNIG, C. S., KRAMS, R., LISHCHUK, S. and SPENCER, T. J. (2011). Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33 (7), 840-848. [Article]

Abstract
More Information
Metrics
Share

[+][-]

Abstract

We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

More Information

Research Institute, Centre or Group - Does NOT include content added after October 2018:

Materials and Engineering Research Institute > Modelling Research Centre > Materials Modelling group

Page Range:

840-848

Identifiers

Identification Number:

10.1016/j.medengphy.2010.09.007

ORCID for I. Halliday: