ZHANG, H., ZHANG, Z. and LAN, L. H. (2010). Evolutionary optimization of a fed-batch penicillin fermentation process. In: 2010 International Symposium on Computer, Communication, Control and Automation, Tainan, 5-7 May 2010. p. 403. [Conference or Workshop Item]
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2525:585
Abstract
This paper presents a genetic algorithms
approach for the optimization of a fed-batch penicillin
fermentation process. A customized float-encoding
genetic algorithm is developed and implemented to a
benchmark fed-batch penicillin fermentation process.
Off-line optimization of the initial conditions and set
points are carried out in two stages for a single variable
and multiple variables. Further investigations with online
optimization have been carried out to demonstrate
that the yield can be significantly improved with an
optimal feed rate profile. The results have shown that the
proposed approaches can be successfully applied to
optimization problems of fed-batch fermentation to
improve the operation of such processes.
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