Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

BRADFORD, Claire M., RAMOS, Inês, CROSS, Alison K., HADDOCK, Gail, MCQUAID, Stephen, NICHOLAS, Anthony P. and WOODROOFE, M. Nicola (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95.

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Abstract

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and control brain white matter. We demonstrate increased citrullinated GFAP and MBP by immunohistochemistry and western blotting in areas of ongoing demyelination, suggesting a pivotal role for deimination of GFAP and MBP in MS pathogenesis MS.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1016/j.jneuroim.2014.05.007
Page Range:	85-95
Depositing User:	Louise Vickers
Date Deposited:	31 Oct 2014 15:04
Last Modified:	18 Mar 2021 04:34
URI:	https://shura.shu.ac.uk/id/eprint/8579

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