Radiation-induced changes in serum lipidome of head and neck cancer patients

JELONEK, Karol, PIETROWSKA, Monica, ROS, Malgorzata, ZAGDANSKI, Adam, SUCHWALKO, Agnieszka, POLANSKA, Joanna, MARCZYK, Michal, RUTKOWSKI, Tomasz, SKLADOWSKI, Krzysztof, CLENCH, Malcolm R. and WIDLAK, Piotr (2014). Radiation-induced changes in serum lipidome of head and neck cancer patients. International Journal of Molecular Sciences, 15 (4), 6609-6624.

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Open Access URL: https://www.mdpi.com/1422-0067/15/4/6609 (Published version)
Link to published version:: https://doi.org/10.3390/ijms15046609


Cancer radiotherapy (RT) induces response of the whole patient’s body that could be detected at the blood level. We aimed to identify changes induced in serum lipidome during RT and characterize their association with doses and volumes of irradiated tissue. Sixty-six patients treated with conformal RT because of head and neck cancer were enrolled in the study. Blood samples were collected before, during and about one month after the end of RT. Lipid extracts were analyzed using MALDI-oa-ToF mass spectrometry in positive ionization mode. The major changes were observed when pre-treatment and within-treatment samples were compared. Levels of several identified phosphatidylcholines, including (PC34), (PC36) and (PC38) variants, and lysophosphatidylcholines, including (LPC16) and (LPC18) variants, were first significantly decreased and then increased in post-treatment samples. Intensities of changes were correlated with doses of radiation received by patients. Of note, such correlations were more frequent when low-to-medium doses of radiation delivered during conformal RT to large volumes of normal tissues were analyzed. Additionally, some radiation-induced changes in serum lipidome were associated with toxicity of the treatment. Obtained results indicated the involvement of choline-related signaling and potential biological importance of exposure to clinically low/medium doses of radiation in patient’s body response to radiation.

Item Type: Article
Additional Information: This article belongs to the Special Issue Mass Spectrometry Application in Biology
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Identification Number: https://doi.org/10.3390/ijms15046609
Page Range: 6609-6624
Depositing User: Louise Vickers
Date Deposited: 05 Nov 2014 13:08
Last Modified: 17 Mar 2021 20:16
URI: https://shura.shu.ac.uk/id/eprint/8596

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