Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

BRADFORD, Claire M., RAMOS, Inês, CROSS, Alison K., HADDOCK, Gail, MCQUAID, Stephen, NICHOLAS, Anthony P. and WOODROOFE, M. Nicola (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95.

[img]
Preview
PDF
1-s2.0-S0165572814001490-main.pdf - Published Version
Creative Commons Attribution Non-commercial No Derivatives.

Download (5MB) | Preview
Official URL: http://dx.doi.org/10.1016/j.jneuroim.2014.05.007
Link to published version:: https://doi.org/10.1016/j.jneuroim.2014.05.007
Related URLs:

    Abstract

    Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and control brain white matter. We demonstrate increased citrullinated GFAP and MBP by immunohistochemistry and western blotting in areas of ongoing demyelination, suggesting a pivotal role for deimination of GFAP and MBP in MS pathogenesis MS.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1016/j.jneuroim.2014.05.007
    Page Range: 85-95
    Depositing User: Louise Vickers
    Date Deposited: 31 Oct 2014 15:04
    Last Modified: 08 Jul 2019 16:31
    URI: http://shura.shu.ac.uk/id/eprint/8579

    Actions (login required)

    View Item View Item

    Downloads

    Downloads per month over past year

    View more statistics