The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme.

GAYER-ANDERSON, Charlotte, JONGSMA, Hannah E, DI FORTI, Marta, QUATTRONE, Diego, VELTHORST, Eva, DE HAAN, Lieuwe, SELTEN, Jean-Paul, SZÖKE, Andrei, LLORCA, Pierre-Michel, TORTELLI, Andrea, ARANGO, Celso, BOBES, Julio, BERNARDO, Miguel, SANJUÁN, Julio, SANTOS, José Luis, ARROJO, Manuel, PARELLADA, Mara, TARRICONE, Ilaria, BERARDI, Domenico, RUGGERI, Mirella, LASALVIA, Antonio, FERRARO, Laura, LA CASCIA, Caterina, LA BARBERA, Daniele, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta, EU-GEI WP2 GROUP, , RUTTEN, Bart P, VAN OS, Jim, JONES, Peter B, MURRAY, Robin M, KIRKBRIDE, James B and MORGAN, Craig (2020). The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme. Social psychiatry and psychiatric epidemiology, 55 (5), 645-657.

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Abstract

Purpose

The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.

Methods

Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.

Conclusions

This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.

Item Type:	Article
Contributors:	Loureiro, Camila [0000-0002-0239-5064]
Uncontrolled Keywords:	EU-GEI WP2 Group; Humans; Incidence; Case-Control Studies; Schizophrenia; Adolescent; Adult; Middle Aged; Brazil; Europe; Female; Male; Young Adult; Gene-Environment Interaction; Ethnicity; Case–control; EU-GEI; Environment–environment interactions; First-episode psychosis; Gene–environment interactions; Incidence; Adolescent; Adult; Brazil; Case-Control Studies; Ethnicity; Europe; Female; Gene-Environment Interaction; Humans; Incidence; Male; Middle Aged; Schizophrenia; Young Adult; 1103 Clinical Sciences; 1701 Psychology; 1702 Cognitive Sciences; Psychiatry; 4202 Epidemiology; 4206 Public health; 5203 Clinical and health psychology
Identification Number:	https://doi.org/10.1007/s00127-020-01831-x
Page Range:	645-657
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	07 Mar 2024 16:22
Last Modified:	08 Mar 2024 02:02
URI:	https://shura.shu.ac.uk/id/eprint/33172

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