Major disruptions of sleep during treatment of the opiate withdrawal syndrome : differences between methadone and lofexidine detoxification treatments

BESWICK, T., BEST, David, REES, S., BEARN, J., GOSSOP, M. and STRANG, J. (2003). Major disruptions of sleep during treatment of the opiate withdrawal syndrome : differences between methadone and lofexidine detoxification treatments. Addiction Biology, 8 (1), 49-57.

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Abstract

Sleep disturbance experienced during methadone or lofexidine opiate detoxification was investigated in 118 opiate-dependent patients receiving inpatient detoxification treatment. Sleep was assessed at four time-points during opiate detoxification using a self-report questionnaire. Maximum sleep disruption occurred at completion of detoxification and during the protracted withdrawal period, with patients in the methadone group reporting higher levels of withdrawal symptoms, lower overall sleep, longer sleep latencies and significantly longer periods of time awake than lofexidine patients. Regression analyses demonstrated a significant relationship between sleep disturbance, protracted withdrawal and retention in treatment, in addition to the major treatment benefit of reduced sleep disturbance conferred by lofexidine treatment.

Item Type:	Article
Additional Information:	Related URL links to erratum published in Vol.8, no.3, p.367
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Law Research Group
Identification Number:	https://doi.org/10.1080/1355621031000069882
Page Range:	49-57
Depositing User:	Hilary Ridgway
Date Deposited:	12 Feb 2015 10:07
Last Modified:	18 Mar 2021 09:30
URI:	https://shura.shu.ac.uk/id/eprint/9241

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