The effectiveness of combined naloxone/lofexidine in opiate detoxification : results from a double-blind randomized and placebo-controlled trial

BESWICK, T., BEST, David, BEARN, J., GOSSOP, M., REES, S. and STRANG, J. (2003). The effectiveness of combined naloxone/lofexidine in opiate detoxification : results from a double-blind randomized and placebo-controlled trial. American Journal on Addictions, 12 (4), 295-305.

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Abstract

The efficacy of lofexidine/naloxone was compared with lofexidine/placebo in a double-blind, randomized, placebo-controlled trial in 89 opiate-dependent patients. There were no significant differences between the two groups in the proportion of patients completing detoxification or in the length of stay. Patients in the active naloxone group demonstrated gradual reductions in levels of withdrawal and craving over the detoxification period. At completion of detoxification, patients who received naloxone maintained a level of withdrawal consistent

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Law Research Group
Identification Number:	https://doi.org/10.1111/j.1521-0391.2003.tb00544.x
Page Range:	295-305
Depositing User:	Hilary Ridgway
Date Deposited:	23 Jan 2015 10:30
Last Modified:	18 Mar 2021 09:30
URI:	https://shura.shu.ac.uk/id/eprint/9238

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