SCOTT, E., DALEY, A. J., DOLL, H., WOODROOFE, N., COLEMAN, R. E., MUTRIE, N., CRANK, H., POWERS, H. J. and SAXTON, J. M. (2013). Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial. Cancer Causes and Control, 24 (1), 181-191.
Abstract
Excess body weight at diagnosis and weight
gain after breast cancer are associated with poorer longterm
prognosis. This study investigated the effects of a
lifestyle intervention on body weight and other health
outcomes influencing long-term prognosis in overweight
women (BMI[25.0 kg/m2) recovering from early-stage
(stage I–III) breast cancer. A total of 90 women treated
3–18 months previously were randomly allocated to a
6-month exercise and hypocaloric healthy eating program
(n = 47, aged 55.6 ± 10.2 year) or control group (n = 43,
aged 55.9 ± 8.9 year). Women in the intervention group
received three supervised exercise sessions per week and
individualized dietary advice, supplemented by weekly
nutrition seminars. Body weight, waist circumference,
waist/hip ratio [WHR], cardiorespiratory fitness, blood
biomarkers associated with breast cancer recurrence and
cardiovascular disease risk, and quality of life (FACT-B)
were assessed at baseline and 6 months. Three-day diet
diaries were used to assess macronutrient and energy
intakes. A moderate reduction in body weight in the
intervention group (median difference from baseline of
-1.09 kg; IQR -0.15 to -2.90 kg; p = 0.07) was
accompanied by significant reductions in waist circumference
(p\0.001), WHR (p = 0.005), total (p = 0.021) and
saturated fat (p = 0.006) intakes, leptin (p = 0.005), total
cholesterol (p = 0.046), and resting diastolic blood pressure(p = 0.03). Cardiopulmonary fitness (p\0.001) and
FACT-B quality of life (p = 0.004) also showed significant
improvements in the intervention group. These findings
suggest that an individualized exercise and a hypocaloric
healthy eating program can positively impact upon health
outcomes influencing long-term prognosis in overweight
women recovering from early-stage breast cancer.
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