A review of the evidence for a protective role of uric acid in Parkinson’s disease

Liu, Hanxiang; Reynolds, Gavin P.

A review of the evidence for a protective role of uric acid in Parkinson’s disease

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LIU, Hanxiang and REYNOLDS, Gavin P. (2025). A review of the evidence for a protective role of uric acid in Parkinson’s disease. npj Parkinson's Disease, 11 (1): 325. [Article]

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Abstract

The relationship between the circulating antioxidant uric acid (UA) and Parkinson’s disease (PD) has attracted much interest. This review of the evidence indicating whether UA may have a protective role in the development and/or progression of PD draws on the findings of reduced serum UA in PD, critically assesses the more equivocal genetic results, and discusses experimental observations that UA may provide protection against the pathogenic mechanisms of PD.

More Information

Official URL:

https://www.nature.com/articles/s41531-025-01169-8...

Open Access URL:

https://www.nature.com/articles/s41531-025-01169-8...

Open Access Version:

Published version

Additional Information:

** From Springer Nature via Jisc Publications Router ** History: received 16-05-2025; registration 29-09-2025; accepted 29-09-2025; epub 19-11-2025; online 19-11-2025; collection 01-12-2025. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ ** Acknowledgements: The authors are grateful for the encouragement of Professor Jie Bai to undertake this review.

Identifiers

Identification Number:

10.1038/s41531-025-01169-8

ORCID for Gavin P. Reynolds: