The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.

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QUATTRONE, Diego, REININGHAUS, Ulrich, RICHARDS, Alex L., TRIPOLI, Giada, FERRARO, Laura, QUATTRONE, Andrea, MARINO, Paolo, RODRIGUEZ, Victoria, SPINAZZOLA, Edoardo, GAYER-ANDERSON, Charlotte, JONGSMA, Hannah E, JONES, Peter B, LA CASCIA, Caterina, LA BARBERA, Daniele, TARRICONE, Ilaria, BONORA, Elena, TOSATO, Sarah, LASALVIA, Antonio, SZÖKE, Andrei, ARANGO, Celso, BERNARDO, Miquel, BOBES, Julio, DEL BEN, Cristina Marta, MENEZES, Paulo Rossi, LLORCA, Pierre-Michel, SANTOS, Jose Luis, SANJUÁN, Julio, ARROJO, Manuel, TORTELLI, Andrea, VELTHORST, Eva, BERENDSEN, Steven, DE HAAN, Lieuwe, RUTTEN, Bart PF, LYNSKEY, Michael T, FREEMAN, Tom P, KIRKBRIDE, James B, SHAM, Pak C, O'DONOVAN, Michael C, CARDNO, Alastair G, VASSOS, Evangelos, VAN OS, Jim, MORGAN, Craig, MURRAY, Robin M, LEWIS, Cathryn M, DI FORTI, Marta and EU-GEI COLLABORATORS (2021). The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study. Translational psychiatry, 11: 423. [Article]

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Abstract
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03-0.33) and positive (B = 0.19; 95%CI 0.03-0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11-0.52) and in controls (B = 0.26; 95%CI 0.06-0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
More Information
Official URL:
http://dx.doi.org/10.1038/s41398-021-01526-0
Open Access URL:
https://www.nature.com/articles/s41398-021-01526-0...
Open Access Version:
Published version
Contributors:
Collaborator - Loureiro, Camila
Uncontrolled Keywords:
EU-GEI collaborators; Humans; Cannabis; Linear Models; Risk Factors; Psychotic Disorders; Schizophrenia; Cannabis; Humans; Linear Models; Psychotic Disorders; Risk Factors; Schizophrenia; 1103 Clinical Sciences; 1117 Public Health and Health Services; 1701 Psychology; 3202 Clinical sciences; 3209 Neurosciences; 5202 Biological psychology
Event Location:
United States

Identifiers

Identification Number:
10.1038/s41398-021-01526-0
ORCID for Diego Quattrone: ORCID iD orcid.org/0000-0002-6051-8309
ORCID for Ulrich Reininghaus: ORCID iD orcid.org/0000-0002-9227-5436
ORCID for Alex L. Richards: ORCID iD orcid.org/0000-0003-3218-7247
ORCID for Giada Tripoli: ORCID iD orcid.org/0000-0002-9257-6677
ORCID for Paolo Marino: ORCID iD orcid.org/0000-0003-3571-1753
ORCID for Victoria Rodriguez: ORCID iD orcid.org/0000-0003-0383-0846
ORCID for Edoardo Spinazzola: ORCID iD orcid.org/0000-0002-8070-0618
ORCID for Charlotte Gayer-Anderson: ORCID iD orcid.org/0000-0003-1636-889X
ORCID for Peter B Jones: ORCID iD orcid.org/0000-0002-0387-880X
ORCID for Caterina La Cascia: ORCID iD orcid.org/0000-0002-2078-0214
ORCID for Sarah Tosato: ORCID iD orcid.org/0000-0002-9665-7538
ORCID for Antonio Lasalvia: ORCID iD orcid.org/0000-0001-9963-6081
ORCID for Celso Arango: ORCID iD orcid.org/0000-0003-3382-4754
ORCID for Miquel Bernardo: ORCID iD orcid.org/0000-0001-8748-6717
ORCID for Julio Bobes: ORCID iD orcid.org/0000-0003-2187-4033
ORCID for Cristina Marta Del Ben: ORCID iD orcid.org/0000-0003-0145-9975
ORCID for Paulo Rossi Menezes: ORCID iD orcid.org/0000-0001-6330-3314
ORCID for Pierre-Michel Llorca: ORCID iD orcid.org/0000-0001-7438-8990
ORCID for Bart PF Rutten: ORCID iD orcid.org/0000-0002-9834-6346
ORCID for Michael T Lynskey: ORCID iD orcid.org/0000-0001-9989-737X
ORCID for Tom P Freeman: ORCID iD orcid.org/0000-0002-5667-507X
ORCID for James B Kirkbride: ORCID iD orcid.org/0000-0003-3401-0824
ORCID for Michael C O'Donovan: ORCID iD orcid.org/0000-0001-7073-2379
ORCID for Evangelos Vassos: ORCID iD orcid.org/0000-0001-6363-0438
ORCID for Craig Morgan: ORCID iD orcid.org/0000-0002-1386-2369
ORCID for Robin M Murray: ORCID iD orcid.org/0000-0003-0829-0519
ORCID for Cathryn M Lewis: ORCID iD orcid.org/0000-0002-8249-8476

Library

Item Type:
Article
SWORD Depositor:
Symplectic Elements
Depositing User:
Symplectic Elements
Date Deposited:
22 Feb 2024 16:16
Last Modified:
18 Dec 2024 17:48
Date of first compliant deposit:
22 February 2024
Date of first compliant Open Access:
22 February 2024
Version of first compliant deposit:
Version of Record
URI:
https://shura.shu.ac.uk/id/eprint/33178
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