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MILLAR, Joshua, OZAKI, Ema, CAMPBELL, Susan, DUCKETT, Catherine, DOYLE, Sarah and COLE, Laura (2022). Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease. Metabolites, 12 (12): 1239.
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Abstract
Determining the locations of proteins within the eye thought to be involved in ocular pathogenesis is important to determine how best to target them for therapeutic benefits. However, immunohistochemistry is limited by the availability and specificity of antibodies. Additionally, the perceived role of both essential and non-essential metals within ocular tissue has been at the forefront of age-related macular degeneration (AMD) pathology for decades, yet even key metals such as copper and zinc have yet to have their roles deconvoluted. Here, mass spectrometry imaging (MSI) is employed to identify and spatially characterize both proteomic and metallomic species within ocular tissue to advance the application of a multiomic imaging methodology for the investigation of ocular diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LA-ICP-MSI; MALDI-MSI; SARM1; age-related macular degeneration; copper; multimodal; ocular disease; zinc; 0301 Analytical Chemistry; 0601 Biochemistry and Cell Biology; 1103 Clinical Sciences |
| Identification Number: | https://doi.org/10.3390/metabo12121239 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 03 Jan 2023 17:52 |
| Last Modified: | 12 Oct 2023 08:17 |
| URI: | https://shura.shu.ac.uk/id/eprint/31235 |
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