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ELDESOUKI, Salma, SAMARA, Kamel A, QADRI, Rama, OBAIDEEN, Anas A, OTOUR, Ahmad H, HABBAL, Omar and AHMED, Samrein (2022). XIST in Brain Cancer. Clinica Chimica Acta, 531, 283-290.
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Abstract
Long non-coding RNAs (lncRNAs) make up the majority of the human genome. They are a group of small RNA molecules that do not code for any proteins but play a primary role in regulating a variety of physiological and pathological processes. X-inactive specific transcript (XIST), one of the first lncRNAs to be discovered, is chiefly responsible for X chromosome inactivation: an evolutionary process of dosage compensation between the sex chromosomes of males and females. Recent studies show that XIST plays a pathophysiological role in the development and prognosis of brain tumors, a heterogeneous group of neoplasms that cause significant morbidity and mortality. In this review, we explore recent advancements in the role of XIST in migration, proliferation, angiogenesis, chemoresistance, and evasion of apoptosis in different types of brain tumors, with particular emphasis on gliomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Long non-coding RNA; XIST; Gliomas; Brain Tumors; Biomarker; Prognosis; Tumorigenesis; Microrna; Biomarker; Brain Tumors; Gliomas; Long non-coding RNA; Microrna; Prognosis; Tumorigenesis; XIST; Brain Neoplasms; Dosage Compensation, Genetic; Female; Humans; Male; RNA, Long Noncoding; X Chromosome Inactivation; Humans; Brain Neoplasms; Dosage Compensation, Genetic; Female; Male; X Chromosome Inactivation; RNA, Long Noncoding; 1103 Clinical Sciences; General Clinical Medicine |
| Identification Number: | https://doi.org/10.1016/j.cca.2022.04.993 |
| Page Range: | 283-290 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 30 Jun 2022 10:24 |
| Last Modified: | 19 Apr 2024 08:01 |
| URI: | https://shura.shu.ac.uk/id/eprint/30392 |
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