Breast Cancer Stem Cell Active Copper(II) Complexes with Naphthol Schiff Base and Polypyridyl Ligands

NORTHCOTE-SMITH, Joshua, JOHNSON, Alice, SINGH, Kuldip, ORTU, Fabrizio and SUNTHARALINGAM, Kogularamanan (2021). Breast Cancer Stem Cell Active Copper(II) Complexes with Naphthol Schiff Base and Polypyridyl Ligands. Inorganics, 9 (1).

[img]
Preview
PDF
Johnson-BreastCancerStem(VoR).pdf - Published Version
Creative Commons Attribution.

Download (1MB) | Preview
Official URL: https://www.mdpi.com/2304-6740/9/1/5
Open Access URL: https://www.mdpi.com/2304-6740/9/1/5/pdf (Published version)
Link to published version:: https://doi.org/10.3390/inorganics9010005

Abstract

<jats:p>Breast cancer stem cells (CSCs) are a sub-population of tumour cells that can promote breast cancer relapse and metastasis. Current treatments are unable to completely remove breast CSCs, therefore it is essential to develop new chemotherapeutics that can remove breast CSCs at clinically compatible doses. Here we present the synthesis, characterisation, and anti-breast CSC properties of copper(II) complexes, [Cu(L2)(1,10-phenanthroline)]PF6 (2) and [Cu(L3)(1,10-phenanthroline)]PF6 (3) comprising of a tridentate (O,N,S) coordinated naphthol Schiff base ligand (L2 = (E)-1-(((2-(methylthio)ethyl)imino)methyl)naphthalen-2-ol or L3 = (E)-1-(((2-(ethylthio)ethyl)imino)methyl)naphthalen-2-ol and 1,10-phenanthroline. The copper(II) complexes (2 and 3) kill breast CSCs, cultured in monolayer and three-dimensional systems, in the micromolar range. Notably, 2 and 3 are more potent towards breast CSC mammospheres than salinomycin (up to 4.5-fold), an established anti-breast CSC agent. Further, cell-based studies indicate that 2 and 3 are readily taken up by breast CSCs and elevate intracellular reactive oxygen species (ROS) levels upon short exposure times (0.5–1 h). The latter is likely to be the underlying mechanism by which 2 and 3 induces breast CSC death.</jats:p>

Item Type: Article
Uncontrolled Keywords: 0302 Inorganic Chemistry
Identification Number: https://doi.org/10.3390/inorganics9010005
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 17 Mar 2022 14:25
Last Modified: 17 Mar 2022 14:30
URI: https://shura.shu.ac.uk/id/eprint/29935

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics