Synthesis of spirocyclic dihydropyrazoles from tosylhydrazones and electron-deficient alkenes

WOOTTON, Timothy and ALLWOOD, Daniel (2022). Synthesis of spirocyclic dihydropyrazoles from tosylhydrazones and electron-deficient alkenes. Organic and Biomolecular Chemistry.

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Abstract

Spirocycles represent a diverse class of molecules which have received significant attention in the pharmaceutical industry due to their broad biological activities and inherent molecular three-dimensionality. Herein, we demonstrate a procedurally simple method for the preparation of a range of spirocyclic dihydropyrazoles. The protocol utilises bench stable cyclic tosylhydrazones, which are trivial to prepare from the parent cyclic ketone without need for purification, and commercially available electron deficient alkenes. The synthetic utility of the core scaffold is also demonstrated to highlight potential for applications in medicinal chemistry and drug development programmes.

Item Type:	Article
Uncontrolled Keywords:	Biomolecular Sciences Research Centre; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; Organic Chemistry
Identification Number:	https://doi.org/10.1039/d2ob00093h
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	03 Feb 2022 16:05
Last Modified:	15 Mar 2022 09:30
URI:	https://shura.shu.ac.uk/id/eprint/29701

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