Using Stereochemistry to Control Mechanical Properties in Thiol–Yne Click‐Hydrogels

MACDOUGALL, Laura J., PÉREZ‐MADRIGAL, Maria M., SHAW, Joshua E., WORCH, Joshua C., SAMMON, Chris, RICHARDSON, Stephen M. and DOVE, Andrew P. (2021). Using Stereochemistry to Control Mechanical Properties in Thiol–Yne Click‐Hydrogels. Angewandte Chemie.

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Abstract

Abstract: The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at the cost of changing another parameter, that in turn affects the physical properties of the material and ultimately influences the cellular response. Herein, we report that by manipulating the stereochemistry of a double bond, formed in situ during gelation, materials with diverse mechanical properties but comparable physical properties can be obtained. Click‐hydrogels that possess a high % trans content are stiffer than their high % cis analogues by almost a factor of 3. Human mesenchymal stem cells acted as a substrate stiffness cell reporter demonstrating the potential of these platforms to study mechanotransduction without the influence of other external factors.

Item Type:	Article
Additional Information:	** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: http://creativecommons.org/licenses/by/4.0/ **Journal IDs: issn 0044-8249; issn 1521-3757 **Article IDs: publisher-id: ange202107161 **History: published 28-10-2021; rev-recd 29-08-2021; submitted 28-05-2021
Uncontrolled Keywords:	Forschungsartikel, cellular mechanoresponsive behaviour, click-chemistry, hydrogels, stereochemistry, thiol–yne nucleophilic addition
Identification Number:	https://doi.org/10.1002/ange.202107161
SWORD Depositor:	Colin Knott
Depositing User:	Colin Knott
Date Deposited:	29 Oct 2021 08:42
Last Modified:	29 Oct 2021 08:45
URI:	https://shura.shu.ac.uk/id/eprint/29224

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