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ToolsLOUREIRO, Camila M, FACHIM, Helene A, CORSI-ZUELLI, Fabiana, SHUHAMA, Rosana, MENEZES, Paulo R, DALTON, Caroline, DEL-BEN, Cristina M, REYNOLDS, Gavin and LOUZADA-JUNIOR, Paulo (2021). The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia. Epigenomics, 13 (12), 927-937. [Article]
Abstract
Aim: We investigated GRIN1, GRIN2A, GRIN2B and LINE-1 DNA methylation in first-episode schizophrenia patients, their nonaffected siblings and age- and sex-matched controls testing for associations between DNA methylation and exposition to childhood trauma. Materials & methods: The Childhood Trauma Questionnaire evaluated the history of childhood trauma. Genomic DNA was bisulfite converted and pyrosequencing was employed to quantify DNA methylation. Results: GRIN2A, GRIN2B and LINE-1 DNA methylation was not associated with childhood trauma in patients, siblings and controls. Siblings with childhood trauma had hypermethylation at CpG1 of GRIN1 compared with siblings without trauma. Conclusion: Childhood trauma may influence GRIN1 methylation in subjects with liability to psychosis, but not in frank schizophrenia or controls.
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Identification Number:
ORCID for Caroline Dalton:
orcid.org/0000-0002-1404-873X
orcid.org/0000-0002-1404-873X
ORCID for Gavin Reynolds:
orcid.org/0000-0001-9026-7726
orcid.org/0000-0001-9026-7726
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