Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications

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ABEDIN, N., ALSHEHRI, A.H.A., ALMUGHRBI, A.M.A., MOORE, O., ALYZA, S., RUSBRIDGE, E.K., MASOOD, N., EGBOWON, B.F., HARGREAVES, A.J., DAFHNIS-CALAS, F. and FITZPATRICK, Anthony (2020). Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications. Polyhedron, 190, p. 114755. [Article]

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Abstract

© 2020 Elsevier Ltd A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti-biofilm properties well below cytotoxic levels.

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Official URL:

https://www.sciencedirect.com/science/article/pii/...

Uncontrolled Keywords:

Coordination chemistry; Halides; Iron; Crystallography; Biofilms; 0302 Inorganic Chemistry; 0306 Physical Chemistry (incl. Structural); 0399 Other Chemical Sciences; Inorganic & Nuclear Chemistry

Page Range:

p. 114755

Identifiers

Identification Number:

10.1016/j.poly.2020.114755

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Item Type:

Article

SWORD Depositor:

Symplectic Elements

Depositing User:

Symplectic Elements