Tools
Tools
WILLIAMS, Laura, BUTLER, John, THIRKETTLE, Martin, STAFFORD, Tom, QUINLIVAN, Brendan, MACGOVERN, Eavan, O’RIORDAN, Sean, REDGRAVE, Peter, REILLY, Richard and HUTCHINSON, Michael (2020). Slowed luminance reaction times in cervical dystonia: disordered superior colliculus processing. Movement Disorders.
|
PDF
Reaction time luminance (003).pdf - Accepted Version All rights reserved. Download (286kB) | Preview |
Abstract
Background: Abnormal temporal discrimination in cervical dystonia is hypothesised to be due to disrupted processing in the superior colliculus. The fast, luminance-based, retino-tectal pathway, projects to the superior colliculus; chromatic stimuli responses, via the retino-geniculo-calcarine pathway, are up to 30ms longer. Methods: In 20 cervical dystonia and 20 age-matched control participants, we compared reaction times to two flashing visual stimuli: (i) a chromatic annulus and (ii) a luminant, non-coloured annulus. Participants pressed a joystick control when they perceived the annulus flashing. Results: Reaction times in control participants were 20ms significantly faster in the luminant condition than the chromatic (p= 0.017). Patients with cervical dystonia had no reaction time advantage in response to the luminant stimulus. Conclusion: Cervical dystonia patients (compared to control participants) demonstrated no reduction in their reaction time to luminant stimuli, processed through the retino-tectal pathway. This finding is consistent with superior colliculus dysfunction in cervical dystonia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1103 Clinical Sciences; 1106 Human Movement and Sports Sciences; 1702 Cognitive Sciences; Neurology & Neurosurgery |
| Identification Number: | https://doi.org/10.1002/mds.27975 |
| SWORD Depositor: | Symplectic Elements |
| Depositing User: | Symplectic Elements |
| Date Deposited: | 22 Jan 2020 11:53 |
| Last Modified: | 17 Mar 2021 16:15 |
| URI: | https://shura.shu.ac.uk/id/eprint/25713 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year