The role of 18F-Sodium Fluoride PET/CT bone scans in the diagnosis of metastatic bone disease from breast and prostate cancer

KULSHRESTHA, Randeep Kumar, VINJAMURI, Sobhan, ENGLAND, Andrew, NIGHTINGALE, Julie and HOGG, Peter (2016). The role of 18F-Sodium Fluoride PET/CT bone scans in the diagnosis of metastatic bone disease from breast and prostate cancer. Journal of Nuclear Medicine Technology, 44 (4), 217-222.

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Abstract

We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of 18F-NaF PET/CT imaging are outlined.

Item Type:	Article
Departments - Does NOT include content added after October 2018:	Health and Well-being > Department of Allied Health Professions
Identification Number:	https://doi.org/10.2967/jnmt.116.176859
Page Range:	217-222
Depositing User:	Beatrice Turpin
Date Deposited:	26 Jul 2018 10:17
Last Modified:	18 Mar 2021 11:15
URI:	https://shura.shu.ac.uk/id/eprint/22050

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