GAINES, Peter A., KOLODGIE, Frank D., CROWLEY, Gordon, HORAN, Steven, MACDONAGH, Megan, MCLUCAS, Emily, ROSENTHAL, David, STRONG, Ashley, SWEET, Michael and PANCHAL, Deepal K. (2018). Sentry bioconvertible inferior vena cava filter: Study of stages of incorporation in an experimental ovine model. International Journal of Vascular Medicine, 2018 (698150).
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Abstract
The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection from pulmonary embolism (PE) and then bioconvert to become incorporated in the vessel wall, leaving a patent IVC lumen. Objective. To evaluate the performance and stages of incorporation of the Sentry IVC filter in an ovine model. Methods. Twenty-four bioconvertible devices and 1 control retrievable filter were implanted in the infrarenal IVC of 25 sheep, with extensive daily monitoring and intensive imaging. Vessels and devices were analyzed at early (≤98 days, n = 10) and late (180 ± 30 days, n = 14 study devices, 1 control) termination and necropsy time-points. Results. Deployment success was 100% with all devices confirmed in filtering configuration, there were no filter-related complications, and bioconversion was 100% at termination with vessels widely patent. By 98 days for all early-incorporation analysis animals, the stabilizing cylindrical part of the Sentry frame was incorporated in the vessel wall, and the filter arms were retracted. By 180 days for all late-incorporation analysis animals, the filter arms as well as frames were stably incorporated. Conclusions. Through 180 days, there were no filter-related complications, and the study devices were all bioconverted and stably incorporated, leaving all IVCs patent.
Item Type: | Article |
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Contributors: | Editor - Kern, John A. |
Additional Information: | ** From Hindawi via Jisc Publications Router. ** History: received 03-03-2018; accepted 09-05-2018; epub 19-07-2018; pub 19-07-2018. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ |
Uncontrolled Keywords: | Research Article |
Departments - Does NOT include content added after October 2018: | Health and Well-being > Department of Allied Health Professions |
Identification Number: | https://doi.org/10.1155/2018/6981505 |
SWORD Depositor: | Margaret Boot |
Depositing User: | Margaret Boot |
Date Deposited: | 23 Jul 2018 11:19 |
Last Modified: | 18 Mar 2021 07:34 |
URI: | https://shura.shu.ac.uk/id/eprint/22041 |
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