Mycotoxin biosensor based on optical planar waveguide

AL-JAWDAH, Ali, NABOK, Aleksey, JARRAH, Radhyah, HOLLOWAY, Alan, TSARGORODSKA, Anna, TAKACS, Eszter and SZEKACS, Andras (2018). Mycotoxin biosensor based on optical planar waveguide. Toxins, 10 (7), p. 272.

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Abstract

The research aim of this work is to develop a simple and highly sensitive optical biosensor for detection of mycotoxins. This sensor is built on a planar waveguide operating on the polarization interferometry principle, i.e., detecting a phase shift between p- and s-components of polarized light developed during the binding of analyte molecules. The operation of the proposed sensor is similar to that of a Mach⁻Zehnder interferometer, while its design is much simpler and it does not require splitting the waveguide into two arms. The refractive index sensitivity of the polarization interferometer sensor was in the range of 5200 radians per refractive index unit (RIU). Several tests were conducted to detect ochratoxin A (OTA) at different concentrations in direct immunoassay with specific antibodies immobilized in the sensing window. The lowest concentration of OTA of 0.01 ng/mL caused a phase shift of nearly one period. The results obtained prove high sensitivity of the sensors, which are capable of detecting even lower concentrations of mycotoxins at the ppt (part-per-trillion) level.

Item Type:	Article
Additional Information:	** From PubMed via Jisc Publications Router. ** History: received 19-04-2018; revised 06-06-2018; accepted 25-06-2018.
Uncontrolled Keywords:	mycotoxins, optical biosensor, planar waveguide, polarization interferometer, refractive index sensitivity
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Materials and Engineering Research Institute > Advanced Coatings and Composites Research Centre > Electronic Materials and Sensors Research Group
Identification Number:	https://doi.org/10.3390/toxins10070272
Page Range:	p. 272
SWORD Depositor:	Margaret Boot
Depositing User:	Margaret Boot
Date Deposited:	19 Jul 2018 13:53
Last Modified:	18 Mar 2021 11:44
URI:	https://shura.shu.ac.uk/id/eprint/21976

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