Omission of surgery in older women with early breast cancer has an adverse impact on breast cancer-specific survival

WARD, S. E., RICHARDS, P. D., MORGAN, J. L., HOLMES, G. R., BROGGIO, J. W., COLLINS, Karen, REED, M. W. R. and WYLD, L. (2018). Omission of surgery in older women with early breast cancer has an adverse impact on breast cancer-specific survival. British Journal of Surgery, 105 (11), 1454-1463.

Preview

PDF Collins-OmissionOfSurgeryInOlderWomen(AM).pdf - Accepted Version All rights reserved. Download (554kB) | Preview

Abstract

Background: Primary endocrine therapy is used as an alternative to surgery in up to 40 per cent of women with early breast cancer aged over 70 years in the UK. This study investigated the impact of surgery versus primary endocrine therapy on breast cancer-specific survival (BCSS) in older women. Methods: Cancer registration data for 2002–2010 were obtained from two English regions. A retrospective analysis was performed for women with oestrogen receptor (ER)-positive disease, using statistical modelling to show the effect of treatment (surgery or primary endocrine therapy) and age and health status on BCSS. Missing data were handled using multiple imputation. Results: Cancer registration data on 23 961 women were retrieved. After data preprocessing, 18 730 of 23 849 women (78⋅5 per cent) were identified as having ER-positive disease; of these, 10 087 (53⋅9per cent) had surgery and 8643 (46⋅1 per cent) had primary endocrine therapy. BCSS was worse in the primary endocrine therapy group than in the surgical group (5-year BCSS rate 69⋅4and89⋅9 per cent respectively). This was true for all strata considered, although the difference was less in the cohort with the greatest degree of co-morbidity. For older, frailer patients the hazard of breast cancer death had less relative impact on overall survival. Conclusion: BCSS in older women with ER-positive disease is worse if surgery is omitted. This treatment choice may contribute to inferior cancer outcomes. Selection for surgery on the basis of predicted life expectancy may permit choice of women for whom surgery confers little benefit.

Item Type:	Article
Additional Information:	** From Crossref via Jisc Publications Router. ** Licence for VoR version of this article starting on 22-05-2018: http://onlinelibrary.wiley.com/termsAndConditions#vor
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Centre for Health and Social Care Research
Identification Number:	https://doi.org/10.1002/bjs.10885
Page Range:	1454-1463
SWORD Depositor:	Margaret Boot
Depositing User:	Margaret Boot
Date Deposited:	31 May 2018 11:47
Last Modified:	18 Mar 2021 06:22
URI:	https://shura.shu.ac.uk/id/eprint/21345

Actions (login required)

View Item

Downloads

Publication Metrics