LASERNA, Victor, FIORANI, Giulia, WHITEOAK, Christopher, MARTIN, Eddy, ESCUDERO-ADÁN, Eduardo and KLEIJ, Arjan W. (2014). Carbon Dioxide as a protecting group : highly efficient and selective catalytic access to Cycliccis-Diol Scaffolds. Angewandte Chemie International Edition, 53 (39), 10416-10419.
Full text not available from this repository.Abstract
The efficient and highly selective formation of a wide range of (hetero)cyclic cis-diol scaffolds using aminotriphenolate-based metal catalysts is reported. The key intermediates are cyclic carbonates, which are obtained in high yield and with high levels of diastereo- and chemoselectivity from the parent oxirane precursors and carbon dioxide. Deprotection of the carbonate structures affords synthetically useful cis-diol scaffolds with different ring sizes that incorporate various functional groups. This atom-efficient method allows the simple construction of diol synthons using inexpensive and accessible precursors and green metal catalysts and showcases the use of CO2 as a temporary protecting group.
Item Type: | Article |
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Identification Number: | https://doi.org/10.1002/anie.201406645 |
Page Range: | 10416-10419 |
Depositing User: | Christopher Whiteoak |
Date Deposited: | 05 Apr 2016 14:41 |
Last Modified: | 18 Mar 2021 22:46 |
URI: | https://shura.shu.ac.uk/id/eprint/11774 |
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