Nerves are more abundant than blood vessels in the degenerate human intervertebral disc

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BINCH, Abbie L. A., COLE, Ashley A., BREAKWELL, Lee M., MICHAEL, Antony L. R., CHIVERTON, Neil, CREEMERS, Laura B., CROSS, Alison and LE MAITRE, Christine (2015). Nerves are more abundant than blood vessels in the degenerate human intervertebral disc. Arthritis research & therapy, 17 (1), p. 370. [Article]

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11349:34176

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11349:34176

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Abstract

Chronic low back pain (LBP) is the most common cause of disability worldwide. New ideas surrounding LBP are emerging that are based on interactions between mechanical, biological and chemical influences on the human IVD. The degenerate IVD is proposed to be innervated by sensory nerve fibres and vascularised by blood vessels, and it is speculated to contribute to pain sensation. However, the incidence of nerve and blood vessel ingrowth, as well as whether these features are always associated, is unknown. We investigated the presence of nerves and blood vessels in the nucleus pulposus (NP) of the IVD in a large population of human discs.

More Information

Official URL:

http://www.arthritis-research.com/content/17/1/370

Research Institute, Centre or Group - Does NOT include content added after October 2018:

Biomedical Research Centre

Page Range:

p. 370

Identifiers

Identification Number:

10.1186/s13075-015-0889-6

ORCID for Alison Cross: