SCOTT, E., DALEY, A. J., DOLL, H., WOODROOFE, N., COLEMAN, R. E., MUTRIE, N., CRANK, H., POWERS, H. J. and SAXTON, J. M. (2013). Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial. Cancer Causes and Control, 24 (1), 181-191.
Full text not available from this repository.Abstract
Excess body weight at diagnosis and weight gain after breast cancer are associated with poorer longterm prognosis. This study investigated the effects of a lifestyle intervention on body weight and other health outcomes influencing long-term prognosis in overweight women (BMI[25.0 kg/m2) recovering from early-stage (stage I–III) breast cancer. A total of 90 women treated 3–18 months previously were randomly allocated to a 6-month exercise and hypocaloric healthy eating program (n = 47, aged 55.6 ± 10.2 year) or control group (n = 43, aged 55.9 ± 8.9 year). Women in the intervention group received three supervised exercise sessions per week and individualized dietary advice, supplemented by weekly nutrition seminars. Body weight, waist circumference, waist/hip ratio [WHR], cardiorespiratory fitness, blood biomarkers associated with breast cancer recurrence and cardiovascular disease risk, and quality of life (FACT-B) were assessed at baseline and 6 months. Three-day diet diaries were used to assess macronutrient and energy intakes. A moderate reduction in body weight in the intervention group (median difference from baseline of -1.09 kg; IQR -0.15 to -2.90 kg; p = 0.07) was accompanied by significant reductions in waist circumference (p\0.001), WHR (p = 0.005), total (p = 0.021) and saturated fat (p = 0.006) intakes, leptin (p = 0.005), total cholesterol (p = 0.046), and resting diastolic blood pressure(p = 0.03). Cardiopulmonary fitness (p\0.001) and FACT-B quality of life (p = 0.004) also showed significant improvements in the intervention group. These findings suggest that an individualized exercise and a hypocaloric healthy eating program can positively impact upon health outcomes influencing long-term prognosis in overweight women recovering from early-stage breast cancer.
Item Type: | Article |
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Uncontrolled Keywords: | UoA26 |
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1007/s10552-012-0104-x |
Page Range: | 181-191 |
Depositing User: | Users 3084 not found. |
Date Deposited: | 13 Dec 2012 09:54 |
Last Modified: | 18 Mar 2021 20:00 |
URI: | https://shura.shu.ac.uk/id/eprint/6552 |
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