The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme.

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GAYER-ANDERSON, Charlotte, JONGSMA, Hannah E, DI FORTI, Marta, QUATTRONE, Diego, VELTHORST, Eva, DE HAAN, Lieuwe, SELTEN, Jean-Paul, SZÖKE, Andrei, LLORCA, Pierre-Michel, TORTELLI, Andrea, ARANGO, Celso, BOBES, Julio, BERNARDO, Miguel, SANJUÁN, Julio, SANTOS, José Luis, ARROJO, Manuel, PARELLADA, Mara, TARRICONE, Ilaria, BERARDI, Domenico, RUGGERI, Mirella, LASALVIA, Antonio, FERRARO, Laura, LA CASCIA, Caterina, LA BARBERA, Daniele, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta, EU-GEI WP2 GROUP, RUTTEN, Bart P, VAN OS, Jim, JONES, Peter B, MURRAY, Robin M, KIRKBRIDE, James B and MORGAN, Craig (2020). The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme. Social psychiatry and psychiatric epidemiology, 55 (5), 645-657. [Article]

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Abstract

Purpose

The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.

Methods

Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.

Conclusions

This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
More Information
Official URL:
https://link.springer.com/article/10.1007/s00127-0...
Open Access URL:
https://link.springer.com/content/pdf/10.1007/s001...
Open Access Version:
Published version
Contributors:
Loureiro, Camila [0000-0002-0239-5064]
Uncontrolled Keywords:
EU-GEI WP2 Group; Humans; Incidence; Case-Control Studies; Schizophrenia; Adolescent; Adult; Middle Aged; Brazil; Europe; Female; Male; Young Adult; Gene-Environment Interaction; Ethnicity; Case–control; EU-GEI; Environment–environment interactions; First-episode psychosis; Gene–environment interactions; Incidence; Adolescent; Adult; Brazil; Case-Control Studies; Ethnicity; Europe; Female; Gene-Environment Interaction; Humans; Incidence; Male; Middle Aged; Schizophrenia; Young Adult; 1103 Clinical Sciences; 1701 Psychology; 1702 Cognitive Sciences; Psychiatry; 4202 Epidemiology; 4206 Public health; 5203 Clinical and health psychology
Page Range:
645-657
Event Location:
Germany

Identifiers

Identification Number:
10.1007/s00127-020-01831-x
ORCID for Charlotte Gayer-Anderson: ORCID iD orcid.org/0000-0003-1636-889X
ORCID for Diego Quattrone: ORCID iD orcid.org/0000-0002-6051-8309
ORCID for Celso Arango: ORCID iD orcid.org/0000-0003-3382-4754
ORCID for Julio Bobes: ORCID iD orcid.org/0000-0003-2187-4033
ORCID for Antonio Lasalvia: ORCID iD orcid.org/0000-0001-9963-6081
ORCID for Laura Ferraro: ORCID iD orcid.org/0000-0002-1205-2356
ORCID for Caterina La Cascia: ORCID iD orcid.org/0000-0002-2078-0214
ORCID for Paulo Rossi Menezes: ORCID iD orcid.org/0000-0001-6330-3314
ORCID for Cristina Marta Del-Ben: ORCID iD orcid.org/0000-0003-0145-9975
ORCID for Bart P Rutten: ORCID iD orcid.org/0000-0002-9834-6346
ORCID for Peter B Jones: ORCID iD orcid.org/0000-0002-0387-880X
ORCID for Robin M Murray: ORCID iD orcid.org/0000-0003-0829-0519
ORCID for James B Kirkbride: ORCID iD orcid.org/0000-0003-3401-0824
ORCID for Craig Morgan: ORCID iD orcid.org/0000-0002-1386-2369

Library

Item Type:
Article
SWORD Depositor:
Symplectic Elements
Depositing User:
Symplectic Elements
Date Deposited:
07 Mar 2024 16:22
Last Modified:
18 Dec 2024 17:46
Date of first compliant deposit:
7 March 2024
Date of first compliant Open Access:
7 March 2024
Version of first compliant deposit:
Version of Record
URI:
https://shura.shu.ac.uk/id/eprint/33172
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