The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia

LOUREIRO, Camila M, FACHIM, Helene A, CORSI-ZUELLI, Fabiana, SHUHAMA, Rosana, MENEZES, Paulo R, DALTON, Caroline, DEL-BEN, Cristina M, REYNOLDS, Gavin and LOUZADA-JUNIOR, Paulo (2021). The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia. Epigenomics, 13 (12), 927-937.

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Abstract

Aim: We investigated GRIN1, GRIN2A, GRIN2B and LINE-1 DNA methylation in first-episode schizophrenia patients, their nonaffected siblings and age- and sex-matched controls testing for associations between DNA methylation and exposition to childhood trauma. Materials & methods: The Childhood Trauma Questionnaire evaluated the history of childhood trauma. Genomic DNA was bisulfite converted and pyrosequencing was employed to quantify DNA methylation. Results: GRIN2A, GRIN2B and LINE-1 DNA methylation was not associated with childhood trauma in patients, siblings and controls. Siblings with childhood trauma had hypermethylation at CpG1 of GRIN1 compared with siblings without trauma. Conclusion: Childhood trauma may influence GRIN1 methylation in subjects with liability to psychosis, but not in frank schizophrenia or controls.

Item Type:	Article
Additional Information:	** Embargo end date: 04-05-2022 ** From Future Science Group via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: published 04-05-2021; online 04-05-2021; accepted 18-04-2021; published 04-2021; submitted 09-12-2020 **License for this article: starting on 04-05-2022, , https://www.future-science-group.com/archiving
Uncontrolled Keywords:	Short Communication, childhood trauma, DNA methylation, first-episode schizophrenia, GRIN1, GRIN2A, GRIN2B, NMDAR genes, siblings
Identification Number:	https://doi.org/10.2217/epi-2020-0451
Page Range:	927-937
SWORD Depositor:	Colin Knott
Depositing User:	Colin Knott
Date Deposited:	05 May 2021 14:11
Last Modified:	20 May 2021 15:33
URI:	https://shura.shu.ac.uk/id/eprint/28605

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