Slowed luminance reaction times in cervical dystonia: disordered superior colliculus processing

WILLIAMS, Laura, BUTLER, John, THIRKETTLE, Martin, STAFFORD, Tom, QUINLIVAN, Brendan, MACGOVERN, Eavan, O’RIORDAN, Sean, REDGRAVE, Peter, REILLY, Richard and HUTCHINSON, Michael (2020). Slowed luminance reaction times in cervical dystonia: disordered superior colliculus processing. Movement Disorders.

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Background: Abnormal temporal discrimination in cervical dystonia is hypothesised to be due to disrupted processing in the superior colliculus. The fast, luminance-based, retino-tectal pathway, projects to the superior colliculus; chromatic stimuli responses, via the retino-geniculo-calcarine pathway, are up to 30ms longer. Methods: In 20 cervical dystonia and 20 age-matched control participants, we compared reaction times to two flashing visual stimuli: (i) a chromatic annulus and (ii) a luminant, non-coloured annulus. Participants pressed a joystick control when they perceived the annulus flashing. Results: Reaction times in control participants were 20ms significantly faster in the luminant condition than the chromatic (p= 0.017). Patients with cervical dystonia had no reaction time advantage in response to the luminant stimulus. Conclusion: Cervical dystonia patients (compared to control participants) demonstrated no reduction in their reaction time to luminant stimuli, processed through the retino-tectal pathway. This finding is consistent with superior colliculus dysfunction in cervical dystonia.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences; 1106 Human Movement and Sports Sciences; 1702 Cognitive Sciences; Neurology & Neurosurgery
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SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 22 Jan 2020 11:53
Last Modified: 17 Mar 2021 16:15

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