Sex-based differences in severity and mortality in COVID-19.

ALWANI, Mustafa, YASSIN, Aksam, AL-ZOUBI, Raed M., ABOUMARZOUK, Omar M., NETTLESHIP, Joanne, KELLY, Daniel, AL-QUDIMAT, Ahmad R. and SHABSIGH, Ridwan (2021). Sex-based differences in severity and mortality in COVID-19. Rev Med Virol, 31 (6). [Article]

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Abstract
The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.
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