NEWTON, K. A., CLENCH, M. R., DESHMUKH, R., JEYASEELAN, K. and STRONG, P. N. (2007). Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, mesobuthus tamulus: biotope-specific variation in the expression of venom peptides. Rapid communications in mass spectrometry, 21 (21), 3467-3476.Full text not available from this repository.
The red scorpion, Mesobuthus tamulus, is found in two distinct biotopes within the Indian state of Maharastra - a tropical, sea-level biotope and a semi-arid biotope, up to 600 m. Scorpions from these two geographical areas show marked differences in toxicity. Using mass spectrometry, we have shown biotope-specific variation in the expression of peptides from scorpions collected from these two distinct areas. Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) and reversed-phase liquid chromatography/electrospray ionisation mass spectrometry (LC/ESI-MS) were assessed as techniques for obtaining mass fingerprint data. On line LC/ESI-MS was judged to be the method of choice and unique biotope-specific mass fingerprints, with key diagnostic markers, were obtained.
|Research Institute, Centre or Group:||Biomedical Research Centre|
|Depositing User:||Ann Betterton|
|Date Deposited:||12 Mar 2008|
|Last Modified:||05 Oct 2010 15:52|
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