Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles

MADEN-WILKINSON, Tom, DEGENS, H, JONES, DA and MCPHEE, JS (2013). Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles. Journal of Musculoskeletal and Neuronal Interactions, 13 (3), 320-328.

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Abstract

Objectives: Magnetic resonance imaging (MRI) and dual-energy x-ray absorptiometry (DXA) were used to examine the thigh lean mass in young and old men and women. Methods: A whole-body DXA scan was used to estimate thigh lean mass in young (20 men; 22.4±3.1y; 18 women; 22.1±2.0y) and older adults (25 men; 72.3±4.9y; 28 women; 72.0±4.5y). Thigh lean mass deter-mined with a thigh scan on the DXA or full thigh MRI scans were compared. Results: Although the thigh lean mass quantified by DXA and MRI in young and older participants were correlated (R2=0.88; p<0.001) the magnitude of the differences in thigh lean mass between young and old was smaller with DXA than MRI (old vs. young men 79.5±13.1% and 73.4±11.2%; old vs. young women 88.6±11.8% and 79.4±12.3%, respectively). Detailed analysis of MRI revealed 30% smaller quadriceps muscles in the older than young individuals, while the other thigh muscles were only 18% smaller. Conclusions: DXA underestimates the age-related loss of thigh muscle mass in comparison to MRI. The quadriceps muscles were more susceptible to age-related atrophy compared with other thigh muscles.

Item Type:	Article
Uncontrolled Keywords:	1103 Clinical Sciences; 1109 Neurosciences; 1116 Medical Physiology; Endocrinology & Metabolism
Page Range:	320-328
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	08 Jun 2021 15:07
Last Modified:	08 Jun 2021 15:15
URI:	https://shura.shu.ac.uk/id/eprint/27972

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