Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications

ABEDIN, N., ALSHEHRI, A.H.A., ALMUGHRBI, A.M.A., MOORE, O., ALYZA, S., RUSBRIDGE, E.K., MASOOD, N., EGBOWON, B.F., HARGREAVES, A.J., DAFHNIS-CALAS, F. and FITZPATRICK, Anthony (2020). Expanding the family of tetrahalide iron complexes: synthesis, structure and biological applications. Polyhedron, 190, p. 114755.

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    © 2020 Elsevier Ltd A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallography. The iron(II) oxidation state is balanced by the protonated pyrazinium nitrogen just outside the coordination sphere. The biological properties of this and two other related complexes are investigated using both Gram-negative and Gram-positive bacteria as well as methicillin resistant strains. They all exhibit some antimicrobial properties albeit at moderate to poor concentrations. However, the tetrahalide complexes analysed exhibit excellent anti-biofilm properties well below cytotoxic levels.

    Item Type: Article
    Uncontrolled Keywords: Coordination chemistry; Halides; Iron; Crystallography; Biofilms; 0302 Inorganic Chemistry; 0306 Physical Chemistry (incl. Structural); 0399 Other Chemical Sciences; Inorganic & Nuclear Chemistry
    Identification Number: https://doi.org/10.1016/j.poly.2020.114755
    Page Range: p. 114755
    SWORD Depositor: Symplectic Elements
    Depositing User: Symplectic Elements
    Date Deposited: 03 Dec 2020 17:22
    Last Modified: 17 Aug 2021 01:18
    URI: http://shura.shu.ac.uk/id/eprint/27713

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