Sentry bioconvertible inferior vena cava filter: Study of stages of incorporation in an experimental ovine model

GAINES, Peter A., KOLODGIE, Frank D., CROWLEY, Gordon, HORAN, Steven, MACDONAGH, Megan, MCLUCAS, Emily, ROSENTHAL, David, STRONG, Ashley, SWEET, Michael and PANCHAL, Deepal K. (2018). Sentry bioconvertible inferior vena cava filter: Study of stages of incorporation in an experimental ovine model. International Journal of Vascular Medicine, 2018 (698150).

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Official URL: https://www.hindawi.com/journals/ijvm/2018/6981505...
Link to published version:: https://doi.org/10.1155/2018/6981505

Abstract

The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection from pulmonary embolism (PE) and then bioconvert to become incorporated in the vessel wall, leaving a patent IVC lumen. Objective. To evaluate the performance and stages of incorporation of the Sentry IVC filter in an ovine model. Methods. Twenty-four bioconvertible devices and 1 control retrievable filter were implanted in the infrarenal IVC of 25 sheep, with extensive daily monitoring and intensive imaging. Vessels and devices were analyzed at early (≤98 days, n = 10) and late (180 ± 30 days, n = 14 study devices, 1 control) termination and necropsy time-points. Results. Deployment success was 100% with all devices confirmed in filtering configuration, there were no filter-related complications, and bioconversion was 100% at termination with vessels widely patent. By 98 days for all early-incorporation analysis animals, the stabilizing cylindrical part of the Sentry frame was incorporated in the vessel wall, and the filter arms were retracted. By 180 days for all late-incorporation analysis animals, the filter arms as well as frames were stably incorporated. Conclusions. Through 180 days, there were no filter-related complications, and the study devices were all bioconverted and stably incorporated, leaving all IVCs patent.

Item Type: Article
Additional Information: ** From Hindawi via Jisc Publications Router. ** History: received 03-03-2018; accepted 09-05-2018; epub 19-07-2018; pub 19-07-2018. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: Research Article
Departments - Does NOT include content added after October 2018: Health and Well-being > Department of Allied Health Professions
Identification Number: https://doi.org/10.1155/2018/6981505
Related URLs:
SWORD Depositor: Margaret Boot
Depositing User: Margaret Boot
Date Deposited: 23 Jul 2018 11:19
Last Modified: 16 Nov 2018 13:52
URI: http://shura.shu.ac.uk/id/eprint/22041

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