Mass spectrometry imaging of 3D tissue models

RUSSO, Cristina, LEWIS, Emily, FLINT, Lucy and CLENCH, Malcolm (2018). Mass spectrometry imaging of 3D tissue models. Proteomics, 18 (14).

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/pm...
Link to published version:: https://doi.org/10.1002/pmic.201700462

Abstract

A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions. Derived from 3D cell culture, organoids are generally small‐scale constructs of cells that are fabricated in the laboratory to serve as 3D representations of in vivo tissues and organs. Due to regulatory, economic and societal issues concerning the use of animals in scientific research it seems clear that the use of 3D cell culture and organoids in for example early stage studies of drug efficacy and toxicity will increase. The combination of such 3D tissue models with mass spectrometry imaging provides a label free methodology for the study of drug absorption/penetration, drug efficacy/toxicity and drug biotransformation. In this article, some of the successes achieved to date and challenges to be overcome before this methodology is more widely adopted are discussed.

Item Type: Article
Additional Information: ** From Crossref via Jisc Publications Router.
Uncontrolled Keywords: Biochemistry, Molecular Biology
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: https://doi.org/10.1002/pmic.201700462
SWORD Depositor: Margaret Boot
Depositing User: Margaret Boot
Date Deposited: 30 Apr 2018 14:10
Last Modified: 21 Aug 2018 09:30
URI: http://shura.shu.ac.uk/id/eprint/20994

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