HARRISON, R., WARD, K., LEE, E., RAZAGHI, H., HORNE, C. and BISHOP, N.J. (2015). Acute bone response to whole body vibration in healthy pre-pubertal boys. Journal of musculoskeletal neuronal interactions, 15 (2), 112-122.Full text not available from this repository.
The skeleton responds to mechanical stimulation. We wished to ascertain the magnitude and speed of the growing skeleton’s response to a standardised form of mechanical stimulation, vibration. 36 prepubertal boys stood for 10 minutes in total on one of two vibrating platforms (high (>2 g) or low (<1 g) magnitude vibration) on either 1, 3 or 5 successive days (n=12 for each duration); 15 control subjects stood on an inactive platform. Blood samples were taken at intervals before and after vibration to measure bone formation (P1NP, osteocalcin) and resorption (CTx) markers as well as osteoprotegerin and sclerostin. There were no significant differences between platform and control groups in bone turnover markers immediately after vibration on days 1, 3 and 5. Combining platform groups, at day 8 P1NP increased by 25.1% (CI 12.3 to 38.0; paired t-test p=0.005) and bone resorption increased by 10.9% (CI 3.6 to 18.2; paired t-test p=0.009) compared to baseline. Osteocalcin, osteoprotogerin and sclerostin did not change significantly. The growing skeleton can respond quickly to vibration of either high or low magnitude. Further work is needed to determine the utility of such “stimulation-testing” in clinical practice.
|Research Institute, Centre or Group:||Materials and Engineering Research Institute > Centre for Automation and Robotics Research > Mobile Machine and Vision Laboratory|
|Identification Number:||PMID: 26032203|
|Depositing User:||Ann Betterton|
|Date Deposited:||02 Dec 2015 12:02|
|Last Modified:||22 Sep 2016 11:19|
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