MALDI and Trace Metal Analysis in Age-Related Macular Degeneration.

MILLAR, Joshua, CAMPBELL, Susan, DUCKETT, Catherine, DOYLE, Sarah and COLE, Laura (2023). MALDI and Trace Metal Analysis in Age-Related Macular Degeneration. In: COLE, Laura and CLENCH, Malcolm, (eds.) Imaging Mass Spectrometry, methods and protocols. Methods in Molecular Biology (2688). Humana, NY., Springer US, 1-13.

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Abstract

Age-related macular degeneration (AMD) remains one of the most prevalent causes of blindness throughout the world. Key to prevention of AMD is furthering the understanding of its pathology. In recent years, both the proteins within the innate immune system and essential and non-essential metals have been implicated in the pathology of AMD. Herein, a multidisciplinary and multimodal methodology has been taken to further our understanding of the role of the innate immune proteins and the essential metals within mouse ocular tissue.

Item Type:	Book Section
Additional Information:	Series E-ISSN: 1940-6029
Uncontrolled Keywords:	Animals; Mice; Macular Degeneration; Trace Elements; Metals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Copper; Innate immune system; LA-ICP-MSI; MALDI-MSI; Metals; SARM1; Zinc; Mice; Animals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Macular Degeneration; Trace Elements; Metals; 0399 Other Chemical Sciences; 0601 Biochemistry and Cell Biology; Developmental Biology; 3101 Biochemistry and cell biology; 3404 Medicinal and biomolecular chemistry
Identification Number:	https://doi.org/10.1007/978-1-0716-3319-9_1
Page Range:	1-13
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	25 Jan 2024 11:31
Last Modified:	25 Jan 2024 11:31
URI:	https://shura.shu.ac.uk/id/eprint/33087

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