Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.

OBJECTIVE : To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.

DESIGN : Observational clinical study.

SETTING : Recurrent miscarriage clinic of a tertiary care teaching hospital.

PATIENT(S) : Patients with history of recurrent miscarriage.

INTERVENTION(S) : Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.

MAIN OUTCOME MEASURE(S) : Serum concentrations of inhibin A and activin A levels.

RESULT(S) : Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.