Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging.

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DJIDJA, Marie-Claude, FRANCESE, Simona, CLAUDE, Emmanuelle, LOADMAN, Paul, SUTTON, Chris, SHYNDER, Steve, COOPER, Patricia, PATTERSON, Laurence H, CAROLAN, Vikki and CLENCH, Malcolm (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225. [Article]

Abstract
In situ investigation and characterisation of hypoxia-related protein markers in AQ4N treated tumour xenografts. MALDI-IMS-MSI enabled the visualisation of the distribution of AQ4N and AQ4 within the tissue sections, hence the selective localisation hypoxic tissue regions. Protein distribution and identification were obtained directly from AQ4N treated and non treated tumour tissue sections after in situ digestion.
More Information
Official URL:
https://www.ingentaconnect.com/contentone/ben/cac/...
Research Institute, Centre or Group - Does NOT include content added after October 2018:
Biomedical Research Centre
Page Range:
212-225

Identifiers

Identification Number:
10.2174/157341113805218884
ORCID:
https://orcid.org/0000-0002-1381-1262https://orcid.org/0000-0001-7384-4018https://orcid.org/0000-0002-0798-831X

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Item Type:
Article
Depositing User:
Rebecca Jones
Date Deposited:
23 Jul 2012 15:19
Last Modified:
18 Mar 2021 05:11
URI:
https://shura.shu.ac.uk/id/eprint/5550
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