Lifting the lid on GPCRs: the role of extracellular loops

WHEATLEY, M, WOOTTEN, D, CONNER, M, SIMMS, J, KENDRICK, R, LOGAN, RT, POYNER, DR and BARWELL, J (2012). Lifting the lid on GPCRs: the role of extracellular loops. British Journal of Pharmacology, 165 (6), 1688-1703.

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Abstract

GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G-protein interaction, it might be assumed that ECL segments merely link the important TMs within the helical bundle of the receptor. However, compelling evidence has emerged in recent years revealing a critical role for ECLs in many fundamental aspects of GPCR function, which supported by recent GPCR crystal structures has provided mechanistic insights. This review will present current understanding of the key roles of ECLs in ligand binding, activation and regulation of both family A and family B GPCRs.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1111/j.1476-5381.2011.01629.x
Page Range:	1688-1703
Depositing User:	Rebecca Jones
Date Deposited:	27 Feb 2012 16:55
Last Modified:	18 Mar 2021 10:30
URI:	https://shura.shu.ac.uk/id/eprint/4868

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