Protrudin in protrudinG invadopodia: Membrane contact sites and cell invasion.

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ARORA, Amita and OLKKONEN, Vesa M (2020). Protrudin in protrudinG invadopodia: Membrane contact sites and cell invasion. The Journal of cell biology, 219 (8): e202006146. [Article]

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Abstract
Invadopodia are dynamic protrusions that harbor matrix metalloproteinases for pericellular matrix degradation. However, the mechanisms underlying their maturation are poorly understood. Pedersen et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202003063) demonstrate a dual role of Protrudin in invadopodia elongation and matrix degradation, central to cell invasion and cancer metastasis.
More Information
Official URL:
https://doi.org/10.1083/jcb.202006146
Open Access URL:
https://rupress.org/jcb/article-pdf/219/8/e2020061...
Open Access Version:
Published version
Uncontrolled Keywords:
Extracellular Matrix; Endosomes; Matrix Metalloproteinases; Exocytosis; Matrix Metalloproteinase 14; Podosomes; Endosomes; Exocytosis; Extracellular Matrix; Matrix Metalloproteinase 14; Matrix Metalloproteinases; Podosomes; 06 Biological Sciences; 11 Medical and Health Sciences; Developmental Biology; 31 Biological sciences; 32 Biomedical and clinical sciences
Event Location:
United States

Identifiers

Identification Number:
10.1083/jcb.202006146
ORCID for Amita Arora: ORCID iD orcid.org/0000-0001-8556-4072
ORCID for Vesa M Olkkonen: ORCID iD orcid.org/0000-0001-5553-7997

Library

Publisher:
Rockefeller University Press
Item Type:
Article
SWORD Depositor:
Symplectic Elements
Depositing User:
Symplectic Elements
Date record made live:
18 Jun 2026 15:29
Last Modified:
18 Jun 2026 15:45
Date of first compliant deposit:
18 June 2026
Date of first compliant Open Access:
18 June 2026
Version of first compliant deposit:
Version of Record
ISSN:
0021-9525
Volume:
219
URI:
https://shura.shu.ac.uk/id/eprint/37496
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