Functionalization of ibuprofen core structure compound: Part 1 Synthesis of potential chemotherapeutic agents incorporated ibuprofen substructure and their in vitro antimicrobial study

A series of overfifteen newly potential chemotherapeutic agents of hydrazides, hydrazones and imides incorporated ibuprofen sub-structure have been synthesized in a very good yield under conventional heat and irradiation conditions. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria as well as antifungal activity. Compound 15 showed the highest antibacterial as well as antifungal activities compared to other compounds with some antifungal activity higher than standard drugs. However compound 14 showed the lowest antibacterial activity but similar antifungal activity compared to other compounds. All compounds have been characterized by IR, ¹H-NMR, ¹³C-NMR and x-ray analyses.