Carbon monoxide affects early cardiac development in an avian model

MATIAS, Filipa Rombo, GROVES, Ian, DURRANS, Joshua and HERIGSTAD, Mari (2024). Carbon monoxide affects early cardiac development in an avian model. Birth Defects Research, 116 (3).

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Introduction: Carbon monoxide (CO) is a toxic gas that can be lethal in large doses and may also cause physiological damage in lower doses. Epidemiological studies suggest that CO in lower doses over time may impact on embryo development, in particular cardiac development, however other studies have not observed this association. Methods: Here, we exposed chick embryos in ovo to CO at three different concentrations (3, 9, 18 ppm) plus air control (4 protocols in total) for the first 9 days of development, at which point we assessed egg and embryo weight, ankle length, developmental stage, heart weight, ventricular wall thickness, ventricular‐septal thickness and atrial wall thickness. Results: We found that heart weight was reduced for the low and moderate exposures compared to air, that atrial wall and ventricular wall thickness was increased for the moderate and high exposures compared to air and that ventricular septal thickness was increased for low, moderate and high exposures compared to air. Ventricular wall thickness was also significantly positively correlated with absolute CO exposures across all protocols. Conclusions: This intervention study thus suggests that CO even at very low levels may have a significant impact on cardiac development.

Item Type: Article
Additional Information: ** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: **Journal IDs: issn 2472-1727 **Article IDs: publisher-id: bdr22330 **History: published_online 15-03-2024; published 03-2024; accepted 28-02-2024; rev-recd 21-02-2024; submitted 19-07-2023
Uncontrolled Keywords: air pollution, carbon monoxide, ventricular morphology, cardiac development, avian model
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SWORD Depositor: Colin Knott
Depositing User: Colin Knott
Date Deposited: 18 Mar 2024 15:29
Last Modified: 18 Mar 2024 15:29

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