Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis.

LOUREIRO, Camila, CORSI-ZUELLI, Fabiana, FACHIM, Helene Aparecida, SHUHAMA, Rosana, CHAGAS, Natália Mota de Souza, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta and LOUZADA-JUNIOR, Paulo (2021). Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciencia & saude coletiva, 26 (3), 1085-1094. [Article]

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Abstract
We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients' siblings (30.3% men). Fisher's exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
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