Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis.

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LOUREIRO, Camila, CORSI-ZUELLI, Fabiana, FACHIM, Helene Aparecida, SHUHAMA, Rosana, CHAGAS, Natália Mota de Souza, MENEZES, Paulo Rossi, DEL-BEN, Cristina Marta and LOUZADA-JUNIOR, Paulo (2021). Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciencia & saude coletiva, 26 (3), 1085-1094. [Article]

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Abstract
We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients' siblings (30.3% men). Fisher's exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
More Information
Official URL:
https://www.scielo.br/j/csc/a/mq55Wtk3vgJSGssMPYxx...
Open Access URL:
https://www.scielo.br/j/csc/a/mq55Wtk3vgJSGssMPYxx...
Open Access Version:
Published version
Uncontrolled Keywords:
Humans; Receptors, N-Methyl-D-Aspartate; Prevalence; Bipolar Disorder; Psychotic Disorders; Schizophrenia; Female; Male; Bipolar Disorder; Female; Humans; Male; Prevalence; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Schizophrenia; 1117 Public Health and Health Services; Public Health; 4206 Public health
Page Range:
1085-1094
Event Location:
Brazil

Identifiers

Identification Number:
10.1590/1413-81232021263.07552019
ORCID for Camila Loureiro: ORCID iD orcid.org/0000-0002-0239-5064
ORCID for Fabiana Corsi-Zuelli: ORCID iD orcid.org/0000-0001-9202-3987
ORCID for Helene Aparecida Fachim: ORCID iD orcid.org/0000-0003-3818-3167
ORCID for Rosana Shuhama: ORCID iD orcid.org/0000-0001-7626-7543
ORCID for Natália Mota de Souza Chagas: ORCID iD orcid.org/0000-0003-0984-9919
ORCID for Paulo Rossi Menezes: ORCID iD orcid.org/0000-0001-6330-3314
ORCID for Cristina Marta Del-Ben: ORCID iD orcid.org/0000-0003-0145-9975
ORCID for Paulo Louzada-Junior: ORCID iD orcid.org/0000-0003-2585-3870

Library

Item Type:
Article
SWORD Depositor:
Symplectic Elements
Depositing User:
Symplectic Elements
Date Deposited:
12 Mar 2024 13:24
Last Modified:
18 Dec 2024 17:45
Date of first compliant deposit:
12 March 2024
Date of first compliant Open Access:
12 March 2024
Version of first compliant deposit:
Version of Record
URI:
https://shura.shu.ac.uk/id/eprint/33173
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