High-intensity interval training in patients with intermittent claudication

PYMER, Sean, HARWOOD, Amy E., PROSSER, Jonathon, WADDELL, Alexander, RHAVINDHRAN, Bharadhwaj, IBEGGAZENE, Said, MCGREGOR, Gordon, HUANG, Chao, TWIDDY, Maureen, NICHOLLS, Adam R., INGLE, Lee, CARROLL, Sean, HE, Heije, LONG, Judith, ROOMS, Marjorie and CHETTER, Ian C. (2023). High-intensity interval training in patients with intermittent claudication. Journal of Vascular Surgery, 78 (4), 1048-1056.

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Official URL: https://www.sciencedirect.com/science/article/pii/...
Open Access URL: https://www.sciencedirect.com/science/article/pii/... (Published version)
Link to published version:: https://doi.org/10.1016/j.jvs.2023.05.045


OBJECTIVE: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effective alternative that is more acceptable to patients and easier to deliver. The aim of this study was to determine the feasibility of HIIT for patients with IC. METHODS: A single arm proof-of-concept study, performed in secondary care, recruiting patients with IC referred to usual-care SEPs. Supervised HIIT was performed three times per week for 6 weeks. The primary outcome was feasibility and tolerability. Potential efficacy and potential safety were considered, and an integrated qualitative study was undertaken to consider acceptability. RESULTS: A total of 280 patients were screened: 165 (59%) were eligible, and 40 (25%) were recruited. The majority (n = 31; 78%) of participants completed the HIIT program. The remaining nine patients were withdrawn or chose to withdraw. Completers attended 99% of training sessions, completed 85% of sessions in full, and performed 84% of completed intervals at the required intensity. There were no related serious adverse events. Maximum walking distance (+94 m; 95% confidence interval, 66.6-120.8 m) and the SF-36 physical component summary (+2.2; 95% confidence interval, 0.3-4.1) were improved following completion of the program. CONCLUSIONS: Uptake to HIIT was comparable to SEPs in patients with IC, but completion rates were higher. HIIT appears feasible, tolerable, and potentially safe and beneficial for patients with IC. It may provide a more readily deliverable, acceptable form of SEP. Research comparing HIIT with usual-care SEPs appears warranted.

Item Type: Article
Uncontrolled Keywords: High-intensity interval training; Intermittent claudication; Supervised exercise program; 11 Medical and Health Sciences; Cardiovascular System & Hematology; 3201 Cardiovascular medicine and haematology; 3202 Clinical sciences
Identification Number: https://doi.org/10.1016/j.jvs.2023.05.045
Page Range: 1048-1056
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 23 Jun 2023 15:57
Last Modified: 11 Oct 2023 11:30
URI: https://shura.shu.ac.uk/id/eprint/32050

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