Right Ventricular Morphology and Function after Exercise Training in People with Systemic Sclerosis: A Randomized Controlled Pilot Study.

ANIFANTI, Maria, TELOUDI, Andriana, MITROPOULOS, Alexandros, SYRAKOU, Niki, PAGKOPOULOU, Eleni, TRIANTAFYLLIDOU, Eva, BOSTRÖM, Carina, DIEDERICHSEN, Louise Pyndt, CUOMO, Giovanna, DIMITROULAS, Theodoros, KLONIZAKIS, Markos and KOUIDI, Evangelia (2023). Right Ventricular Morphology and Function after Exercise Training in People with Systemic Sclerosis: A Randomized Controlled Pilot Study. Life, 13 (2): 545.

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Official URL: https://www.mdpi.com/2075-1729/13/2/545
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99589... (Published)
Link to published version:: https://doi.org/10.3390/life13020545
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Background: Vascular dysfunction and its concomitant multi-organ involvement, including cardiac involvement, affects prognosis in systemic sclerosis (SSc) patients. Regular exercise has demonstrated to be able to improve vascular function in SSc. However, the effects of an exercise program on the heart and specifically in right ventricular (RV) morphology and function in SSc have yet to be explored. The study aimed to examine whether a 3-month combined exercise program can affect RV morphology and function in SSc patients. Methods: Twenty-eight SSc patients were randomly allocated to either the exercise training (ET) or the control (CON) group. Baseline and follow-up assessments consisted of a cardiopulmonary exercise test along with both a conventional and a two-dimensional speckle tracking echocardiography (2DSTE) focused on RV morphology and function. Following the baseline assessments, Group ET participated in a supervised combined exercise program for 12 weeks, while group CON received their usual care. Results: The ET group demonstrated increases in peak oxygen consumption by 25.1% (p < 0.001), global RV free wall longitudinal systolic strain by 6.69% (p < 0.03), RV free wall longitudinal systolic strain of the basal segment by 13.5% (p < 0.001), and global RV four-chamber longitudinal systolic strain by 6.76% (p < 0.03) following the exercise program. No differences were observed in group CON. Conclusions: Combined exercise improved cardiorespiratory efficiency and indices of RV systolic function, as assessed by the 2DSTE, in SSc patients.

Item Type: Article
Uncontrolled Keywords: cardiopulmonary exercise testing; echocardiography; exercise training; right ventricular function; systemic sclerosis; 3101 Biochemistry and cell biology; 3104 Evolutionary biology; 4601 Applied computing
Identification Number: https://doi.org/10.3390/life13020545
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 28 Feb 2023 16:00
Last Modified: 11 Oct 2023 16:47
URI: https://shura.shu.ac.uk/id/eprint/31599

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